Adaptive immunology
T- and B-cell biology, antigen-specific responses, and immune memory.
Academic profile · Bangkok, Thailand
Waradon
SungnakPhD
Lecturer / Department of Microbiology
Faculty of Science, Mahidol University
I bring together human immunology, single-cell and multi-omics, adaptive immune receptor (AIR) sequence and repertoire informatics, and human genomics. My research examines how antigen-specific T- and B-cell responses vary across people and disease, and how immune history and host genetic variation relate to immune-cell state and function.
Academic appointments
Affiliations
- Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
- Integrative Computational BioScience (ICBS) Center, Mahidol University, Nakhon Pathom, Thailand
- Single-cell Omics and Systems Biology of Diseases (scSyBiD) Research Unit, Faculty of Science, Mahidol University, Bangkok, Thailand
Academic training
Training and perspective
My training spans biochemistry, immunology, and computational biology. It shaped a research path from molecular immune mechanisms to data-rich studies of human immune responses.
- 2012
Columbia University
BA, Biochemistry
Undergraduate research with Sankar Ghosh - 2019
Harvard University
PhD, Immunology
Doctoral research with Vijay Kuchroo - 2021
Wellcome Sanger Institute
Postdoctoral training, immunology and bioinformatics
Research with Sarah Teichmann
Research and expertise
Connecting immune biology and computation.
I bring together human immunology, single-cell and multi-omics, adaptive immune receptor (AIR) sequence and repertoire informatics, and human genomics. My research examines how antigen-specific T- and B-cell responses vary across people and disease, and how immune history and host genetic variation relate to immune-cell state and function.
Single-cell and multi-omics
Approaches for resolving immune-cell states and response variation in human samples.
AIR sequence and repertoire informatics
Computational analysis of adaptive immune receptor sequences, clonotypes, and repertoire structure.
Human genomics
Connecting host genetic variation with immune-cell state and function.
Integrative human immunology
Bringing experimental biology and computational analysis together across infection and immune-mediated disease.
Research output
Publications
Heterogeneity and dynamics of DENV-specific CD8+ T cells in dengue infection
Nature Communications, 17, 7103 (2026)
https://doi.org/10.1038/s41467-026-73491-5Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome
Scientific Reports, 15, 15612 (2025)
https://doi.org/10.1038/s41598-025-99628-yDistinct systemic immune responses in asymptomatic and symptomatic dengue virus infection
Science Translational Medicine, 17(829), eads5932 (2025)
https://doi.org/10.1126/scitranslmed.ads5932Local and systemic responses to SARS-CoV-2 infection in children and adults
Nature, 602(7896), 321–327 (2022)
https://doi.org/10.1038/s41586-021-04345-xSingle-cell multi-omics analysis of the immune response in COVID-19
Nature Medicine, 27(5), 904–916 (2021)
https://doi.org/10.1038/s41591-021-01329-2SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Nature Medicine, 26(5), 681–687 (2020)
https://doi.org/10.1038/s41591-020-0868-6T follicular regulatory cell-derived fibrinogen-like protein 2 regulates production of autoantibodies and induction of systemic autoimmunity
The Journal of Immunology, 205(12), 3247–3262 (2020)
https://doi.org/10.4049/jimmunol.2000748Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics
Advances in Immunology, 141, 1–31 (2019)Book chapter
https://doi.org/10.1016/bs.ai.2018.12.001Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
Nature Immunology, 17, 1436–1446 (2016)
https://doi.org/10.1038/ni.3578Articles and a book chapter. Bibliographic details link to publisher or PubMed records.
Education
Teaching
I contribute to undergraduate and graduate education in immunology, bioinformatics, and research design. My teaching develops logical and critical thinking, helps learners formulate clear questions and sound study designs, choose appropriate comparisons and analytical approaches, interpret evidence, and communicate findings through scientific writing. I also support training at the interface of immunology, single-cell and multi-omics methods, and data science.
- Logical and critical thinking
- Formulating research questions and designing studies
- Selecting suitable comparisons and analytical approaches
- Interpreting evidence and communicating findings through scientific writing
- Training across immunology, single-cell and multi-omics methods, and data science
Working across teams
Research networks
Communities and cross-institutional networks connected to my research.
- Center of Excellence in Single-cell Omics of Infectious Disease
- Dengue Immune Single-cell Omics (DISCO)
- Human Cell Atlas
- Mahidol AI Center (MU AI Center)
- Genomics Thailand
Open materials
Resources
Getting started with R, the command line, and single-cell analysis? Visit the learning resources page for a suggested path and supplementary teaching materials.
Learning resourcesA curated set of public datasets, code, protocols, and analysis resources will appear here as they are ready to share.
Research resources · Datasets · Code · ProtocolsContact & profiles